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Continuous blood sugar increases euglycemia (Diabetes Care 2004;27:734-738., 2004-03-09)
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Titel: Continuous blood sugar increases euglycemia Från: Diabetes Care 2004;27:734-738. Datum: 2004 03 09 |
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Drug & Device Development
Continuous blood sugar monitoring increases euglycemia
Continuously available information on blood
glucose levels provided by a subcutaneously implanted sensor significantly
decreases periods of hyperglycemia and hypoglycemia in adults with type 1
diabetes, physicians report in the March issue of Diabetes Care.
Although intensive diabetes management is associated with improved outcomes,
it is also linked to increases in the number of hypoglycemic episodes, Dr. Satish
K. Garg, at the University of Colorado Health Sciences Center in Denver, and
associates note. They theorized that real-time continuous glucose readings
would increase time spent in euglycemia.
For their study, DexCom glucose sensors (San Diego, California) were
i mplanted into subcutaneous tissue of the abdomen of 15 patients with type 1
diabetes.
The devices are comprised of a sensor about the size of an AA battery that
transmits radio signals to a pager-sized receiver. Glucose levels are determined
every 30 se conds, and data are transmitted to the receiver every 5 minutes.
Vibratory and auditory alarms go off when glucose levels are too high or too
low.
During a blinded study period of approximately 50 days, blood glucose levels
were stored in the receiver, b ut were not made available to physicians or
patients. During the second unblinded period, averaging 44 days, the receiver
displays were activated. Patients were requested to monitor their blood glucose
levels at least twice daily with a traditional self-m onitoring device and whenever
an alarm sounded.
During the unblinded period, patients spent on average 47% less time per day in
the hypoglycemic range and 25% less time in the hyperglycemic range, even
though patients were instructed not to make therapeu tic adjustments based on
sensor data.
Dr. Garg's group suggests that infrequent self-monitored blood glucose
measurements fail to provide patients with enough information to avoid
hypoglycemia. They suggest that, by decreasing glucose excursions, continu ous
glucose readings may improve quality of life and reduce the complications of
diabetes.
Diabetes Care 2004;27:734-738.
NyhetsINFO 2004 03 09
www red DiabetologNyttt
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